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Dose modification represents a common management strategy

They are non-viral delivery systems derived from classic liposomes, where the introduction of (permanent or transient) positively charged lipids that have strong electrostatic associations with RNA polymers provides larger payloads of this biomolecules (Wittrup and Lieberman, 2015

Gut microbiota might act as a negative feedback mechanism to maintain the homeostasis of BAs and PUFAs via FGF19 signalling and PUFA saturation, respectively

doi: 10.1126/scitranslmed.3009098 305 WuXGeHLemonBVonderfechtSWeiszmannJHechtRet al

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Cuprizone induces apoptosis of mature oligodendrocytes that leads to a robust demyelination and profound activation of both astrocytes and microglia with regional heterogeneity between different white and gray matter regions