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Part I: Exposure, Evaluation, and treatment

Introduction Aminoacyl-tRNA synthetases (ARSs) are generally considered as housekeepers involved in protein synthesis, whose primary function is to catalyze the aminoacylation of transfer RNAs (tRNAs)

Rare but more serious side effects may include prolonged erections (priapism), sudden hearing or vision loss, and allergic reactions

A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain

Stockler-Ipsiroglu S, Apatean D, Battini R, DeBrosse S, Dessoffy K, Edvardson S, Eichler F, Johnston K, Koeller DM, Nouioua S, Tazir M, Verma A, Dowling MD, Wierenga KJ, Wierenga AM, Zhang V, Wong LJ (2015) Arginine:glycine amidinotransferase (AGAT) deficiency: clinical features and long term outcomes in 16 patients diagnosed worldwide

It was found that both AOD9604 and hGH resulted in fat loss in association with increased fat oxidation as well as increased levels of glycerol (relating to lipolysis), However, an added benefit of AOD9604 was that it did not lead to hyperglycemia in the mice or reduced insulin sensitivity