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Previously, our lab developed strategies targeting membranous CD147, such as the anti-CD147 metuximab to prevent tumor recurrence 55 and enhance the chemosensitivity of pancreatic CSCs 56 , as well as anti-CD147 scFv-derived chimeric antigen receptor T (CAR-T) cells for inhibiting T cell acute lymphoblastic leukemia 57

2021b;407(2):112800

Combination therapy of acute myeloid leukemia by dual PI3K/mTOR inhibitor BEZ235 and TLR-7/8 agonist R848 in murine model

Conclusion: NAFLD patients with high soluble TREM2 serum levels might be at increased risk of disease progression, and potentially benefit from a closer surveillance

The most common neurodegenerative diseases, such as Alzheimers (AD), Huntingtons (HD) and PD, are all marked by the accumulation of misfolded proteins, which play a crucial role in the dysfunction or loss of neurons through their deposition within cells or the extracellular matrix (Singh et al., 2019)

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