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the rest is excreted in the urine

Its classical signaling, via membrane-bound IL-6 receptors, activates STAT3 to promote epithelial regeneration and hepatic acute-phase protein synthesis, responses generally considered anti-inflammatory

10.1042/BST20140226

Finally, reduced excitotoxicity and improved overall handling of glutamate could be achieved through improved metabolism (e.g., increased ATP production) in astrocytes, which are responsible for the uptake of glutamate from the synaptic cleft (113)

J., Nobili, F., Teunissen, C

Recently, various high-throughput-based omics studies have been used to screen for NP toxicity, including genomics, transcriptomics, proteomics, metabolomics, etc., (Matysiak et al., 2016