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The combination of homozygous ATP8B1 p.R952Q and heterozygous ABCB11 p.A444V correlated with serum alkaline phosphatase levels (p=0.001)

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They compared the proteomics results of fibroblasts obtained from BALF and biopsies from SSc-ILD patients and found only three DEPs, indicating that BALF and biopsy fibroblast cultures from SSc-ILD patients were similar in protein composition ( Lung tissue is also an ideal sample type for CTD-ILD proteomic studies

Cell surface biotinylation further showed ZIP8 and ZIP14 on both membranes of human brain microvascular endothelial cells (hBMVECs), with ZIP8 more abundant apically and ZIP14 basolaterally, though not statistically significant (Steimle et al., 2019)