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Cerebrovascular diseases have been associated with cognitive decline and dementia (c.f., vascular dementia (63)), and represent a common comorbidity with significant impacts on the onset and progression of NDDs (64, 65)

Reduced Glutathione helps protect the body from free radicals at the cellular level and promote the detoxification of harmful compounds.

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Mitochondria cannot manufacture glutathione de novo , so glutathione is synthesized in the cytosol and a small fraction of the total cellular pool is then imported into the mitochondrial matrix by carrier-mediated transport (22