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Gamidov SI, Ovchinnikov RI, Popova AY

doi: 10.1038/nrmicro2910 46 WhiteT

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Tirzepatide can promote weight loss and support metabolic health by controlling these factors

SIRT2 deacetylates Smad2 and promotes its ubiquitination at K451, deacetylates Smad3 at K341 and K378, and reduces the phosphorylation, acetylation, and nuclear translocation of Smad2 and Smad3 in the kidneys of UUO mice to inhibit the activation of Smad2 and Smad3, ultimately mitigating kidney injury in the UUO mice model (Yang et al., 2023)

Dosing Protocol Standard Research Protocol Dose: 300mcg per day subcutaneous Timing: Fasted ideally 3060 minutes before eating or exercise Injection site: Lower abdomen or thigh (standard subQ technique) Frequency: Daily, or 5 days on / 2 days off Cycle length: 812 weeks, then 46 week break Reconstitution AOD-9604 dissolves readily in bacteriostatic water (BAC water) no acetic acid required, unlike some hydrophobic peptides