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1,25(OH)2D3 has been shown to suppress mitogen-stimulated IgG production in peripheral blood mononuclear cells from both healthy individuals and inactive SLE patients, indicating a direct inhibitory effect on IgG synthesis (180)

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Finally, several metabolic diseases such as aminoaciduria, organic aciduria, urea cycle and fatty acid oxidation defects, mitochondrial disorders and acute intermittent porphyria should be ruled out (86)

However, not all studies supported a direct link between melatonin suppression and tumorigenesis

Agents that stimulate the adrenergic receptors, such as isoproterenol or salbutamol, activate cell metabolism, reducing the amount of triglycerides stored in the adipocytes