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Oxidized-low density lipoprotein (Ox-LDL) induced ferroptosis and iron accumulation were observed in mouse aorta endothelial cells, and this event can be reversed by ferroptosis inhibitors [17]

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Therefore, targeting the transport and metabolism of glutamine will become a promising therapeutic strategy for the treatment of NSCLC (34)

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16 Likewise, the GLS gene, located in chromosome 2, encodes two splice variants with high activity and low substrate affinity, kidney-type glutaminase (KGA, long transcript isoform) and glutaminase C (GAC, short transcript isoform), which are mainly expressed in the kidney under healthy conditions