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Notably, these studies showed that higher retention and SUVR values for amyloid-beta proteins in specific brain regions was associated with APOE4 in PD subjects with mild cognitive impairment and/or dementia, highlighting APOE4 s potential role in influencing enhanced regional amyloid-beta pathology

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3.4.4 Summary Preclinical studies consistently demonstrate that metformin attenuates DOX-induced cardiotoxicity through coordinated modulation of oxidative stress, mitochondrial dynamics, autophagy, apoptosis, and inflammation