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These proteins, acting as cyclin-dependent kinase (Cdk) inhibitors, lead to the arrest of the G1 phase, and activation of the senescence pathway [90]

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Lastly, lifestyle-integrated approaches, such as time-restricted eating (TRE) combined with low-dose antioxidants, may amplify endogenous defenses while minimizing pharmacological risks (Varady et al., 2022)

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First, there is considerable heterogeneity in study designs, including wide variations in the dosage, bioavailability, and treatment duration of supplements (e.g., -3 PUFAs, collagen peptides), which complicates direct comparison and meta-analysis

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