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Failures in drug development can often be attributed to gaps in our understanding of the biological underpinnings of human diseases, an overreliance on nonhuman models, and deficiencies such as low specificity, suboptimal pharmacological properties, or severe adverse reactions to drugs

Ninety percent of patients treated with digestive enzymes experienced a reduction in symptoms like diarrhea

Having previously conducted a series of investigations of the oxidative damage theory that did not support it [34-38], we were curious about the life-extending effect of GSH, which is consistent with this theory

Additional drugs such as the nerve protective agent olesoxime and the ion channel-targeting neurosteroids have been established promising effect on CIPN in preclinical studies, which, however, are required to be further confirmed in human studies (Table 1 )

10.1002/smll.201001886 85 PrietoT.MarconR

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