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Broader analysis across multiple clinical trials suggests that approximately 10% of patients across all indications and doses may discontinue semaglutide due to GI complaints, which is comparable to or slightly higher than other GLP-1 receptor agonists

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Exploratory analyses revealed links between ghrelin and eating-related depressive symptoms, and that higher BMI was more strongly associated with depressive symptoms in females than males

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Novo Nordisk has been investigating CagriSema through the REDEFINE programme, a series of Phase 3 clinical trials in adults with overweight or obesity

"The discovery and development of liraglutide and semaglutide." Frontiers in Endocrinology , 10, 155