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Similarly, treatment with withaferin A, a steroidal lactone significantly increased expression of HO-1 in HUVECs and EA.hy926 endothelial cells by enhancing nuclear translocation of Nrf2

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BBB functions as a selective barrier that regulates the transport of molecules between blood and CNS, keeping necessities of nutrients and neurotransmitters in the brain

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So, different clusters of clock neurons play different roles in circadian regulation