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The mechanisms underlying ferroptosissuch as iron overload, lipid metabolism dysregulation, and antioxidant defense failureare increasingly recognized as key contributors to neuronal loss and functional deterioration in these disorders

Hepatology 57 , 15751584 (2013)

10.1016/j.redox.2024.103213 77 KapposL.RadueE.-W.OConnorP.PolmanC.HohlfeldR.CalabresiP.et al (2010)

Mechanistically, the abnormal proliferation of these tumor cells was due to the reduction of Asp synthesis through inhibiting Gln oxidation and attenuating reductive carboxylation following GOT1 deletion, which disrupted nucleotide generation within the cells

Induction of the AOX1D isoform of alternative oxidase in A

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