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86 It has been observed in animal models that sustained glucocorticoid stimulation can increase the excitability of glutamatergic neurons and simultaneously decrease the number and plasticity of astrocytes, in addition to decreasing neuronal dendrite connectivity in the hippocampus and frontal cortex, leading to depression

For example, if you have severe hypertension (high blood pressure) that might limit the amount of physical work you can safely do, but is controlled with drugs so that your blood pressure is normal, DDS would consider your impairment "not severe." Similarly, a seriously nearsighted person whose vision can be made clear with glasses doesn't have a severe impairment

It is through that boundary-pushing, done thoughtfully, that the field will mature

Persistent headaches warrant protocol reassessment

Sustained weight loss is more likely when individuals adopt a balanced and nutritious diet, engage in regular physical activity, and make sustainable behavioral modifications

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