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Postherpetic neuralgia (PHN) is a nerve pain (neuralgia) that persists after a shingles rash has cleared

Other than patients who have had their stomachs bypassed, there is also an autoimmune condition known as pernicious anemia that leads to a deficiency of intrinsic factor, lack of ability to absorb vitamin B12 and therefore poor availability of cobalamin (vitamin B12)

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Temperature shock can cause precipitation, where the peptide crashes out of solution and forms visible particles that indicate permanent damage