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It also inhibits RSL3-induced ferroptosis in HT22 cells and reverses I/R injury through the GPX4/ACSL4/ACSL3 axis and PINK1-Parkin-mediated mitochondrial autophagy regulation (170, 171)

In particular, low-dose nicotinic acid is often co-administered with 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins), the cornerstone of treatment of hyperlipidemia, a major risk factor for CHD