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Although a relatively higher prevalence of comorbid conditions, such as DM and HTN, which are well-known risk factors of CKD progression, has been reported among the patients with RA (11), the result from the subgroup analyses in the current study suggests that RA is directly, rather than the aggravation of underlying comorbidities, associated with the progression of CKD, as the association of RA with the risk of ESRD was significantly stronger among those without obesity, DM, HTN, DL, or CKD

No clonal selection was carried out to prevent single clone artefacts

Long-term safety data for high-dose supplementation in healthy aging populations remains limited

Succinate deposition increases HIF-1 stability, epigenetic alterations, and IL-1 synthesis by suppressing -ketoglutarate-dependent enzymes (Loftus and Finlay 2016)

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RBT-3: fruits turned pink