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Melatonin, which is secreted by the pineal gland and regulated by the hypothalamic SCN, follows a distinct circadian rhythm, peaking at night and decreasing during the day (45)

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If personnel take pyridostigmine in advance of exposure, soman will be prevented from binding to a significant percentage of available synaptic AChE because the AChE binding sites will be transiently occupied by pyridostigmine, and so irreversible soman aging (formation of a covalent bond) to the enzyme cannot take place

To understand how these conditions compare, we first need to establish what each one actually involves