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It also counteracts oxidative stress, downregulates pro-inflammatory cytokine expression, preserves mitochondrial membrane potential, and inhibits caspases-3, -8, and -9, thereby preventing neuronal apoptosis (91)

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GSNO plays a key role in nitric oxide-mediated cellular signaling and can regulate protein function through a process called S-nitrosylation

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This review discusses the roles and underlying mechanisms of various forms of PCD in diminished ovarian reserve, while summarizing the current findings on natural products that influence granulosa cells PCD to protect ovarian function