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Among these, gutka, naswar, paan, khaini, and zarda were locally prepared and available in loose packaging, while paan masala was tested using the most common commercial brand (Rajni Brand)

Pharmacology Research & Perspectives, 6(6), e00459

Permeabilization was performed with 0.5% Triton X-100 in PBS for 5 min

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Under caspase-8 inhibition, RIPK1/RIPK3 phosphorylation initiates necrosome formation and MLKL activation, triggering membrane breakdown and the release of pro-inflammatory damage-associated molecular patterns (DAMPs) (Fritsch et al., 2019