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Crucially, this diabetes-induced gut microbiota dysbiosis may profoundly adversely affect the ENS and impede GI motility, as evidenced by recent mechanistic investigations ( Figure 2 )

An informed consent and assent were obtained from each patient and control (whenever applicable) and their legal guardians before enrolment in the study

The Brain and the Role of Mitochondria in MCAS Brain cells, both neuronal and glial, are susceptible to mitochondrial dysfunction due to their high demand for the energy-carrying molecule adenosine triphosphate (ATP)

(2020) 52:e13816

Many of the experiments reviewed here rely on pharmacologic G6PD inhibition or G6PD siRNA knockdown

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