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The commonality between reward systems involved in drug addiction and natural rewards has led to a search for novel agents that can modify these macro-level brain reward systems

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Hydroxocobalamin readily converts to methylcobalamin, an active coenzyme form of B12, without introducing additional methyl groups for "overmethylators" or those who are sensitive to methylated B vitamins.* For another non-methyl B12 option, consider our Adeno B12

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Although this inhibition was not necessarily homogenous at the single neuron level (Fig