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Description

NRF2 appears to be a key mechanistic link between circadian oscillations in redox balance and clock gene expression rhythms

GPX converts peroxides and hydroxyl radicals to non-toxic forms by oxidizing GSH to glutathione disulfide, which is then reduced to GSH by glutathione reductase ( The antioxidant response is modulated mainly by the Nrf2/Keap1 system (Figure 2)

For adult cardiomyocytes and fibroblasts isolation 75 , C57BL/6 J wild-type, Bnip3 / , Flag-Bnip3 ki/ki and Flag-Bnip3 / mice were killed by cervical dislocation

It is likely that variations in experimental methods, biological systems, as well as the distinct metabolic characteristics of cells contributed to the variability in reported results 18,23