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Flora SJ, Bhattacharya R, Vijayaraghavan R

Interestingly, both in vitro and in vivo studies report that V-type and the adjacent C1-type domains are able to form structural and functional VC1 tandem unit with multiple binding sites to recognize numerous different RAGE ligands (8789)

Microglial ferroptosis has been shown to amplify neurotoxicity by releasing pro-inflammatory mediators (such as TNF- and IL-1), and ferroptosis-related genes including ACSL4 and ALOX15 are highly enriched in microglia within PVL lesions