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Unfortunately, in a recent phase 2 multicentre, randomised, placebo-controlled trial of tocilizumab on 36 patients with DM/PM, the trial failed to meet its primary and secondary endpoints

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Conclusion: CADASIL, one of the most prevalent hereditary small vessel diseases, may present with predominantly inflammatory or demyelinating lesions in the brain and spinal cord, diverging from the typically known vascular manifestations