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The oxidative stress-induced caspase 3 activation and apoptosis is prevented by the increased GSH synthesis and GSH level [112]

This often leads to fatigue and dizziness among patients, making it challenging to stay active and continue treatment

(PubMed) Pledgie-Tracy A, Sobolewski MD, Davidson NE

G.AryalB.Canfrn-DuqueA.GoldbergE

The treatment was repeated on Day 7

We selected pAcF as the handles for constructing conjugates instead of other chemistry such as azide mediated click chemistry as the cyclopropane-tetrazine ligation employed in the pAcF system demonstrates superior bioorthogonality compared to azide-alkyne cycloadditions, effectively minimizing off-target reactions in complex cellular environments