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C 1 was then used to drive the distribution of 7,8-DHF to the brain using a physiologically based PK model with perfusion-limited distribution (Figure 1)

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Studies of children who have been maltreated, and those raised in institutions, have confirmed that indiscriminate behavior, the central feature of the phenotype, is increased compared to that in children who have not experienced such extremes of care (7,1119)