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All recommendations are tailored, with risks, benefits, and alternatives clearly explained

In recent years, ECMO has emerged as the standard of care in specialized ICUs for patients with severe ARDS (118, 119)

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Mitophagy regulates mitochondrial number and energy through removing impaired mitochondria (Reference Palikaras, Lionaki and Tavernarakis78)

Evidence (sorafenib): A phase III, randomized, double-blind, placebo-controlled study (DECISION [NCT00984282]) evaluated the activity of sorafenib in patients with progressive, iodine-refractory, differentiated thyroid cancer.[21] The trial included 417 patients with locally advanced or metastatic RAIrefractory thyroid cancer (papillary, follicular [including Hrthle cell], and poorly differentiated, not anaplastic tumors, defined as beyond well-differentiated tumors or those well-differentiated tumors that become resistant to radioiodine treatment) whose disease had progressed within the past 14 months

Cell 111 , 483493 (2002)