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at the rate of 10 C./min, the sample then being maintained for 5 min at 145 C

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We used mice from a somatic transgenic model of MYCdriven liver tumorigenesis 28, which also have elevated MYC and depleted GCLC protein expression (Fig EV3A)

Separations were performed on an Acquity BEH C18 column (2.1 100 mm) with 1.7 m particles from Waters (Milford, MA, USA), maintained at 40 C during separation

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