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ceramides can stimulate aPKCs and inhibit Akt via PP2A, providing a mechanistically plausible route to IR [244]

In summary, although current first-line medications can alleviate DPN pain to some extent, their efficacy is limited, coverage is insufficient, and they lack functional repair effects

In layman's terms, heat breaks proteins down into smaller bits, including kokumi peptides

a randomized double-blind controlled clinical trial

The enteric nervous system is a distributed brain-like bunch of neurons and other cells spread throughout our abdomen that may be able to act independently of our big brain

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