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Moreover, gut microbiota can influence neurotransmitter metabolism either directly by producing neurotransmitters such as GABA, serotonin, and dopamine or indirectly by modulating precursor availability [108, 151]

Therapeutic strategies involving lactate modulation have shown promising effects across these disease contexts, and a summary of representative lactate-targeted therapies across multiple disease models is provided in Table 3

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To account for storage time effects, we combined the Red Cross and in-house samples to obtain normal value ranges for frozen blood samples (n=337)