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In parallel, SIRT1-deficient T cells are more proliferative, produce more IL-2 and exhibit greater susceptibility to experimental autoimmune encephalomyelitis (EAE) (53)

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In addition, HLA-DR genes and their products have been found to play a role in the regulation of the immune system, both in resistance and susceptibility to different infectious agents (90, 96)

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Self-Management Given the direct link of gout to uric acid levels, managing it depends primarily on a strategy for eating well and managing the intake of foods that contribute to increased uric acid levels