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Flippases, namely P4-ATPases like ATP11A and ATP11C, actively translocate aminophospholipids (PS and PE) from the outer to the inner leaflet by an ATP-dependent mechanism (42, 45)

Research indicates that lignans possess biological activities including antitumor, antioxidant, and antimicrobial properties ( Coumarin is a series of compounds containing a coumarin ring structure that is composed of a benzene ring and a pyran ring connected by carbon atoms (Sharifi-Rad et al., 2021)

A great number of epidemiological studies have demonstrated a correlation between ethanol consumption and the occurrence of cancers in many organs

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Furthermore, while 4-HNE promotes cyst growth via multiple kinase pathways (270), the hierarchical integration of these pathways (e.g., which is the rate-limiting step) and their crosstalk with ferroptosis core networks (e.g., lipid peroxidation amplification) are poorly defined

J Carcinog 5:14 Zhang L, Ravipati AS, Koyyalamudi SR, Jeong SC, Reddy N, Smith PT, Bartlett J, Shanmugam K, Mnch G, Wu MJ (2011) Antioxidant and anti-inflammatory activities of selected medicinal plants containing phenolic and flavonoid compounds