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Base standards on evidence, when possible

doi:10.7759/cureus.8166 Spartalis M, Spartalis E, Tzatzaki E, et al

Doing so can help to ease symptoms such as sleep disruption, fatigue, irritability, and mild depression

Reduced effectiveness despite consistent dosing can also indicate degradation, though this is harder to confirm objectively

(87) noted in their review that co-encapsulation systems can effectively mask the astringency of different bioactive compounds, enhance their stability and bioavailability, and maximize their biological effects through synergistic interactions