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This discrepancy could be a consequence of the regulation of distinct sets of longevity genes in the studied organisms, a difference in the conditions used during each of these studies or a combination of the two reasons as well as other yet unknown factors

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Hypopigmentation (depigmentation) denoted areas of depigmented (atrophied) retinal pigment epithelium that did not meet the requirements for geographic atrophy: being less well defined (that is, having less sharp edges), less regularity in shape (such as less circular- or oval-shaped), and/or less severe (i.e., underlying choroid was less visible) than geographic atrophy

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