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Another study in agricultural workers from East Texas identified a significant increased risk (OR = 10.9) of PD with the continuous use of rotenone [53]

These effects were observed in both in vitro and in vivo models, indicating a strong potential for SiO 2 NPs to initiate and develop PD-like symptoms (74)

CTF1,Cardiotrophin-1

Furthermore, mitochondrial GPX4 (GPX4 mito ) cooperates with the dihydroorotate dehydrogenase/CoQ 10 H 2 pathway and the glycerol-3-phosphate dehydrogenase 2 (GPD2)/CoQ 10 H 2 pathway on the inner mitochondrial membrane to inhibit ferroptosis [56, 57] (Fig

Nature Reviews Drug Discovery 23 , 98 (2024) doi: Competing Interests The authors of this article are employees of The Boston Consulting Group (BCG), a management consultancy that works with the world's leading biopharmaceutical companies

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