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29 Popular antioxidants in this system include enzymes that repair damaged DNA (polymerases, glycosylases, and nucleases), along with proteolytic enzymes (proteinases, proteases, and peptidases)

This is highly significant, as it reveals that rare mutations in the HRD motifs of protein kinases are highly penetrant and disease-causing, which provides a strong functional rationale for the R311C mutation in the HRD motif of CaMKK2 being considered a potential monogenic model of bipolar 1 disorder