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For instance, it should be considered that the activity of the mesial temporal cortex, involved in the control of memory and food intake in the central nervous system (CNS), is functionally impaired in dementia

Likewise, improving gut health can help quell, lessen, or even eliminate the problem

To address the critical issue of BBB permeability, studies using [H]Dihexa and [C]inulin in rats revealed that Dihexa avidly concentrated in all examined brain regions including the prefrontal cortex, hippocampus, hypothalamus, striatum, thalamus, midbrain, brain stem, and cerebellum, compared to blood

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This underscores the urgent need for innovative, multi-target therapeutic strategies that can effectively step in ADs complex pathogenesis