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On the other hand, increasing evidence suggests that NO promotes tumor angiogenesis, metastasis, and anti-apoptotic processes (Chen et al., 2021

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The TME becomes more acidic because of hypoxia-induced metabolic abnormalities, which creates a barrier to antitumor immune activity (81)

Medical therapy in acromegaly

Andreeff M, Zeng Z, Kelly MA, R-Y W, McQueen T, Duvvuri S, Nowshad G, Borthakur G, Burger J, Kadia T, Jabbour E, Cortes J, Kantarjian H, Konopleva M

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