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Additionally, it has been established as a therapeutic option for some neurological disorders such as Parkinsons disease, Alzheimers disease, and multiple sclerosis (3840)

Neuen, B

Hasan RA, Koh AY, Zia A

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[DOI] [PMC free article] [PubMed] [Google Scholar] 61.Himmelreich N., Montioli R., Bertoldi M., Carducci C., Leuzzi V., Gemperle C., Berner T., Hyland K., Thny B., Hoffmann G.F., et al

Thus, unlike the DR-1 element positioned close to the SHBG transcription start site, and which functions through interactions with COUP-TF and HNF-4 as the main transcriptional on-off switch in the liver 8 , the upstream DR-1 element that interacts with CAR may represent a fine-tuner that responds to a number of related NHRs many of which regulate responses to metabolic disturbances during disease or after exposure to drugs or environmental xenobiotic ligands