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Activated microglia, reactive gliosis and scar formation critically affect brain remodelling and neural regeneration after ischemic insult
PLoS One 5 , e10386 (2010)
Its function has been described as a shield at the airliquid interface to protect the lung epithelium from environmental stress ( enu1 mutant mouse ( enu1 mutant mice were protected against asthma, despite the presence of cellular glutathione deficiency and oxidant stress in lung airway epithelial cells ( enu1 mutant mice, thereby allowing study of their lung response to inflammation ( enu1 mouse was protected against asthma in this model by an increased size of the extracellular LLF glutathione pool which buffered oxidant species derived from inflammatory cells, and preserved airway epithelial cell barrier function
Flow cytometry analysis of single-strand DNA damage in neuroblastoma cell lines using the F7-26 monoclonal antibody
This can cause oxidative stress and even trigger cell death.[ref] Low levels of BH4 are associated with several types of cardiovascular disease, including high blood pressure, heart disease, and cardiac hypertrophy