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82171134), the Natural Science Foundation of Guangdong Province (Grant No

Effect of high-dose ibuprofen in patients with cystic fibrosis

doi: 10.1371/journal.pone.0205708, 69

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Mechanistic studies have revealed that BBR effectively enhances the regenerative capacity of intestinal stem cells (ISCs) in both healthy and radiation-damaged mouse models by synergistically activating the mammalian target of rapamycin complex 1 (mTORC1), signal transducer and activator of transcription 3 (STAT3), and extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathways (Tu et al., 2024)