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It is noteworthy that SP is also efficient in directly inhibiting RANKL-induced osteoclast differentiation, which plays a synergistic role in remodeling bone homeostasis in RA (Fig

[DOI] [PubMed] [PMC] Jaeschke H, Adelusi OB, Akakpo JY, Nguyen NT, Sanchez-Guerrero G, Umbaugh DS, et al

Yet, the obvious disparity and contradictions of these topographical and biochemical explanations suggest that these may only be pieces of a broader, and probably more complex, picture

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