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After this period, the vial should be discarded even if visually clear, since preservative-treated but not sterile vials accumulate microbial burden over extended use periods

Sarshekeh AM, Advani S, Overman MJ, Manyam G, Kee BK, Fogelman DR, Dasari A, Raghav K, Vilar E, Manuel S, Shureiqi I, Wolff RA, Patel KP, Luthra R, Shaw K, Eng C, Maru DM, Routbort MJ, Meric-Bernstam F, Kopetz S

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Additionally, curcumins redox activity induces excessive ROS accumulation within bacterial cells, further inhibiting bacterial growth or inducing cell death [49]

doi: 10.3389/fonc.2022.1054399 428 NezbedovaLMcGhieTChristensenMHeyesJNasefNAMehtaS

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