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It is synthesised within cells in two sequential ATP-dependent steps, and maintained in its biologically active reduced form (GSH) through the activity of glutathione reductase using NADPH

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High doses of glucocorticoids for an extended period bind to the mineralocorticoid receptor, raising sodium levels and decreasing potassium levels

Between 70-75% of total calories were provided by fat, with the remaining less than 5% of calories provided by carbohydrate intake

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References Foyer, C