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Accompanied by systemic symptoms (fever, fatigue, headache) Unchanging intense pigmentation lasting longer than three weeks

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Nicotine can directly act on brain regions outside the mesolimbic dopamine system, such as the central linear nucleus and parabrachial nucleus, and manifests rewarding effects independent of dopamine through interactions with opioid receptors or other neuropeptides, suggesting a multi-system interactive rewarding integration mechanism (Neugebauer et al., 2011

Hongbin Li, Shihezi University, China Updates Copyright 2022 Ma, Xu, Lang, Zhou, Zhang and Zhang

Affects both eyes simultaneously

doi: 10.1016/J.CBI.2014.01.012 103 CuiSBilitewskiU