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The ability of RAS-GRF1 to activate KRAS was significantly enhanced with increasing Ca 2+ concentration, revealing the internal communication and mutual regulation between KRAS signalling and Ca 2+ signalling as well as metabolism 30,31

Krupa et al., 2019)

The American journal of clinical nutrition 76 (5): 1183S7S

Clinicians might consider berberine as an adjunct in patients with metabolic syndrome or hyperlipidemia who require extra risk factor reduction or cannot tolerate higher doses of standard drugs