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For example, there may be a competition for glutamine between immune and tumor cells, and cell-programmed glutamine partitioning may happen between these cells in the TME

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The core of this process is the homeostasis imbalance of the methyl donor S-adenosylmethionine (SAM) (Xia et al

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For instance, L-Gln antagonists like acivicin, 6-Diazo-5-oxo-L-norleucine (DON), and azaserine caused significant gastrointestinal side effects and neurotoxicity